Abstract
Metrifonate is an acetylcholinesterase (ACh) inhibitor that has been used in the treatment of schistosomiasis for over 30 years. It is not metabolized by the cytochrome P450 enzyme system and is associated with only mild gastrointestinal side effects. These two studies document the efficacy of metrifonate for enhancing the cognitive function of patients with Alzheimer's disease. The first study randomized 480 patients with AD to …
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