Abstract
The convulsions produced by the intravenous injection of metrazol (pentamethylentetrazol) as a therapeutic agent in schizophrenia, were recorded by means of normal and ultra-high-speed motion pictures and by electromyograms. The electromyograms of the activity of antagonistic muscles were recorded simultaneously by 2 matched amplifier systems which operated crystal actuated ink-writing recorders.The typical metrazol seizure in man is composed of 3 stages: the first clonic stage, the tonic stage and the second clonic stage. The nature of the clonus is entirely different in the 2 clonic stages. As seen from the films and the electromyograms the clonus of the first clonic stage is the result of the alternating contraction of agonistic and antagonistic muscle groups; 2 to 4 of these 2-phase movements occurring per second. The second clonic stage is the result of an alternation between simultaneous contraction and relaxation of all muscle groups. It represents an alternating disappearance and reappearance of t...
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