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Abstract
Background: Beta-blockers (BB) slow pathologic remodeling and improve outcomes in patients with symptoms due to systolic left ventricular dysfunction (LVD). It is not known whether BB exert similar effects in asymptomatic patients with systolic LVD. The REVERT (Reversal of Ventricular Remodeling with Toprol-XL) Trial tested the hypothesis that BB slow or reverse remodeling in patients with asymptomatic LVD. Stable NYHA I patients with LVEF <0.40 and LV end-diastolic volume index (LVEDVI) >75 ml/m2 were randomized to placebo vs.
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