Abstract
In the U.S., treatment of nausea and vomiting during early pregnancy usually involves pyridoxine (vitamin B6) and antihistamines, such as doxylamine succinate, promethazine, or meclizine. If these agents are not effective, clinicians might turn to more-potent antiemetics, such as the dopamine antagonist metoclopramide. To assess the association between metoclopramide use during early pregnancy and risk for …
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