Abstract
Abstract The effect of oral metiamide, a new drug that selectively inhibits effects of histamine not inhibited by conventional antihistaminic drugs, on basal and peptone-meal-stimulated gastric acid secretion was studied in 17 patients with duodenal ulcer. All three doses tested (100, 200, and 300 mg) significantly inhibited acid secretion. Basal acid secretion decreased by more than 80 per cent after 200 or 300 mg. Stimulated acid secretion decreased by more than 80 per cent after 300 mg. Inhibition of acid secretion correlated better with peak blood level than with ingested dose. H2-receptor antagonists may be useful in treatment of patients with peptic ulcer. (N Engl J Med 291:373–376, 1974)
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