Abstract
A trial of antiadrenergic and antiseretonergic drugs in the treatment of 24 newly diagnosed and previously untreated infantile spasm patients is reported from the Epilepsy Research Center, Section of Neurophysiology, Department of Neurology, Baylor College of Medicine; the Methodist Hospital; and Texas Children’s Hospital; Houston, TX.
Highlights
Factors related by multivariate analysis to relapse were neurologic abnormalities and organic etiology, mental retardation, seizure type, and appearance or persistence of EEG abnoimalities during the course of the illness and before discontinuation of the drugs
The authors believe that drug withdrawal can be attempted In" patients with well controlled idiopathic epilepsy, without signs of brain damage and without persistent EEG
A trial oT antiadrenergic and antiseretonergic drugs in the treatment of 24 newly diagnosed and previously untreated infantile spasm patients is reported from the Epilepsy Research Center, Section of Neurophysiology, Department of Neurology, Baylor College of Medicine; the Methodist Hospital; and Texas Children's Hospital; Houston, TX
Summary
Factors related by multivariate analysis to relapse were neurologic abnormalities and organic etiology, mental retardation, seizure type (infantile spasms, absence seizures), and appearance or persistence of EEG abnoimalities during the course of the illness and before discontinuation of the drugs. (Matricardi M et al Outcome after discontinuation of antiepileptic drug therapy in children with epilepsy. The authors believe that drug withdrawal can be attempted In" patients with well controlled idiopathic epilepsy, without signs of brain damage and without persistent EEG They stress that predictive factors must be considered to individualize the risk of relapse for each patient.
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