Abstract
The in vitro conversion of the synthetic steroidal androgen melhyltrienolone (17β-hydroxy-17α-methylestra-4, 9, 11-trien-3-one) to an estrogen was investigated. First, with a placental microsome preparation a 10-fold molar excess of methyltrienolone did not affect the aromatization of testosterone. Therefore, methyltrienolone did not compete with testosterone in this very active aromatase system, nor did it inhibit the aromatization. Second, while the placental aromatase very efficiently converted testosterone to estrogens, it did not convert methyltrienolone [ 3H] to estrogenic (phenolic) products. Third, homogenates of rat hypothalamic tissue were also unable to aromatize methyltrienolone, although they converted small quantities of testosterone to estradiol and 19-hydroxyandrostenedione to estrone. This lack of aromatization of methyltrienolone is consistent with observations of additional behavioral and in vivo biochemical experiments.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
