Abstract
BackgroundMethylsulfonylmethane (MSM) is a commonly used diet supplement believed to decrease the inflammation in joints and fastens recovery in osteoarthritis, gastric mucosal injury, or obesity-related disorders. It was also suggested that MSM might play a beneficial role in cancer treatment.PurposeSo far, the MSM might have a potentially beneficial effect in endometrial cancer (EC) treatment.Study designThis study evaluated the effect and usefulness of MSM in combinatory therapy with known drug doxorubicin (DOX).MethodsThe effect of combinational treatment of MSM and DOX on the induction of apoptosis was evaluated in EC cell lines (ISHIKAWA, MFE-296, MFE-280).ResultsWe observed that MSM itself induces apoptosis in EC cell lines, and pre-treatment with MSM for 24 h increases the sensitivity of EC cells to DOX-induced apoptosis and DNA damage and that effect might be regulated by p42/44 (Erk1/2) MAPK and Akt (protein kinase B).ConclusionThese results for the first time show that MSM might act as a sensitizer of EC cells to known drugs, for which EC cells quickly acquire resistance.Graphical abstract
Highlights
One of the most common diseases is cancer
Three different Endometrial cancer (EC) in vitro models were used: ISHIKAWA cells derived from well-differentiated adenocarcinoma, representing histological grade 1 (G1); MFE-296 cells derived from moderately differentiated adenocarcinoma, representing histological grade 2 (G2); and MFE-280 cells derived from poorly differentiated endometrial carcinoma, representing histological grade 3 (G3)
We evaluated the effect of MSM on EC cells and observed that MSM decreases the viability of EC cells in a dose-dependent manner (Fig. 1a)
Summary
One of the most common diseases is cancer. It is estimated that approximately 40% of human population will be diagnosed with cancer in some point of their life. Type I of EC constitutes 80–90% of all ECs. Type I of EC constitutes 80–90% of all ECs It is associated with increased estrogen level, Cell Biol Toxicol (2021) 37:261–275 obesity, and young age of women and is characterized by a good prognosis of patients (Gupta 2017). DOX is a cytostatic drug obtained from Streptomyces peucetius fungi used for the treatment of solid tumors and hematologic cancers since the 1960s (Mathias et al 2019). DOX is believed to be most active in the S phase, it is a cell cycle-nonspecific drug. Highlights MSM induces apoptosis in endometrial cancer cells. MSM sensitizes endometrial cancer cells to DOX-induced apoptosis. MSM increases oxidative stress induced by DOX in EC cells.
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