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Abstract
Purpose: The purpose of the present study was to compare the effect of intramuscular masseter administration of methylprednisolone using a split-mouth design, as a single 20-mg dose, after removal of impacted lower third molars. Patients and Methods: A non-blind, cross-over, comparative, non-randomized, clinical trial was planned. The sample was composed of 32 patients requiring extraction under local anesthesia of two lower bony impacted mandibular third molars. The difficulty of extraction was similar in all cases. The patients received 20 mg of methylprednisolone injected into the masseter muscle via the intrabuccal approach, immediately after suturing of the surgical wound on the right side. The left side received no intramuscular corticoid. Evaluations were made of postoperative pain and swelling. Results: A total of 32 subjects requiring surgical removal of two impacted mandibular third molars under local anesthesia were included in the present study. The patients administered methylprednisolone showed superior results after surgery in terms of pain and facial swelling parameters using self-evaluation, with statistically significant differences versus the control-side (p
Highlights
IntroductionSeems a logical goal, if healing is not compromised, and the use of corticosteroids has gained wide acceptance [3]
The extraction of impacted lower third molars is the most common operation in oral surgery and usually produces pain, trismus and facial swelling in the postoperative period [1], because the region of surgery is mostly composed of loose connective tissue that contains blood and lymph vessels, a series of functional and structural alterations is expected after extraction, mostly expressed as pain, swelling, and trismus [2]
When a procedure required more than 1.5 hours or there was a significant difference between the right side and left side procedure, the patient was removed from the study sample
Summary
Seems a logical goal, if healing is not compromised, and the use of corticosteroids has gained wide acceptance [3]. These agents act by inhibiting the body’s inflammatory response to injury through various mechanisms, with a reduction of fluid transudation and oedema [4]. Over several decades many studies have reported the effectiveness of corticosteroids given before or just after removal of third molars in improving recovery [5,6,7,8,9,10,11,12]. The technique is convenient for the surgeon, as the injection is given in close proximity to the operative field, and for the patient, as the injection is given into an anaesthetised area
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