Abstract
The effectiveness of methylphenidate (MPH), 0.3 and 0.5 mg/kg 2x daily, in the treatment of 31 children, aged 4 to 6 years, with attention-deficit hyperactivity disorder (ADHD) was investigated by a double-blind, placebo-controlled study at the University of Ottawa, Canada.
Highlights
The effectiveness of methylphenidate (MPH), 0.3 and 0.5 mg/kg 2x daily, in the treatment of 31 children, aged 4 to 6 years, with attention-deficit hyperactivity disorder (ADHD) was investigated by a double-blind, placebocontrolled study at the University of Ottawa, Canada
Mania with pervasive developmental disorder is reported in 14 children, representing 21% of a group of PDD subjects, in a study at the Massachusetts General Hospital (Wozniak J, Biederman J, Faraone SV, et al J Am Acad Child Adolesc Psychiatry November 1997;36:1552-1559)
Aggression in boys with ADHD was associated with parent aggressive behavior and lower 5-HT, central serotonergic function in a study of 41 boys at Queens College, Flushing, NY
Summary
The effectiveness of methylphenidate (MPH), 0.3 and 0.5 mg/kg 2x daily, in the treatment of 31 children, aged 4 to 6 years, with attention-deficit hyperactivity disorder (ADHD) was investigated by a double-blind, placebocontrolled study at the University of Ottawa, Canada. Mania with pervasive developmental disorder is reported in 14 children, representing 21% of a group of PDD subjects, in a study at the Massachusetts General Hospital (Wozniak J, Biederman J, Faraone SV, et al J Am Acad Child Adolesc Psychiatry November 1997;36:1552-1559). Comorbid mania among patients with PPD may be more common than previously thought.
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