Abstract
Objective: Estimate the HPV frequency and types in neoplastic thyroid tissue by means of Polymerase Chain Reaction-Restriction Fragments Length Polymorphisms (PCR-RFLP). Method: Transversal study. We analyzed 157 samples from malignant and benign thyroid tumors of paraffin-embedded tissue. All the paraffin blocks were randomly chosen from the archive of Pathology Tissue Bank (Centro Medico Nacional de Occidente, IMSS). The molecular detection and typing was performed at Molecular Microbiology II Laboratory in CIBO. Results: The HPV observed frequency was 2.5% (4 cases). HPV-6 was found in 2 cases of thyroid hyperplasia (2.5%) and HPV-33 in 2 cases of Papillary Cancer (4.6%). Conclusion: HPV is not frequent in thyroid neoplasms, at least in the studied population. The HPV types found were HPV-6 in hyperplasia and HPV-33 in papillary cancer.
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