Abstract
BackgroundIn adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children.MethodsA retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine.ConclusionCompared with the wild-type genotype, the T/T genotype was associated with an increased risk of any type of migraine, though the statistical significance was greatest in migraine with aura. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine.
Highlights
In adult studies the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children
The aim of this study was to evaluate any association between MTHFR T/T polymorphism, high homocysteine serum levels and migraine, in a large pediatric population
Patients with migraine were only included in the study if they had been investigated for MTHFR C677T polymorphism and serum homocysteine levels at their first examination for diagnostic purposes, with the aim of trying to exclude secondary causes of migraine
Summary
In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine. The prevalence of migraine in the pediatric population ranges from 3.3 to 21.4% and increases from childhood to adolescence [1]. It is frequently accompanied by comorbid conditions and can have a significant negative impact on children’s quality of life and school performance [1].
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