Methylenetetrahydrofolate Reductase Genotypes, Dietary Habits and Susceptibility to Stomach Cancer

Abstract

OBJECTIVE To study the relation among methylenetetrahydrofolate reductase (MTHFR) C677T genotypes, dielary habits and the risk of stomach cancer (SC). METHODS A case-control study was conducted with 107 cases of SC and 200 population-based controls in Chuzhou district, Huaian. Jiangsu province, China. The epiderniological data were collected, and DNA of peripheral blood leukocytes was obtained from all of the subjects. MTHFR genotypes were detected by PCR-RFLP. RESULTS (1) The prevalence of the MTHFR C/T or Ttq genotypes was found to be significantly different between conlrols (685%) and SC cases (79.4%. P---0 0416), the increased risk had an adjusted OR of 1.79 (95%Cl: 1.01 - 3.19). (2) Among subjects who had a low intake of garlic or Chinese onion, MTHFR C/T or T/T genotypes significantly increased the risk of developing SC. Among non-tea drinkers or among subjects who had a frequent intake of meat: the carriers of the MTHFR C/'T or T/T genotypes had a higher risk of SC than individuals with the C/C type MTHFR. CONCLUSION The potyrnorphism of MTHFR C677T was associated with increased risk of developing SC, and that individuals with differing genotypes may have different susceptibilities to SC, based on their expos[ire tevel to environmental factors.