Abstract
Genetic factors and environmental factors play a role in pathogenesis of esophageal squamous cell carcinoma (ESCC). Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk. MEDLINE, EMBASE and the Chinese Biomedical Database were searched in our study. The quality of studies were evaluated by predefined scale, and The association of polymorphisms of MTHFR C677T and folate intake and ESCC risk was estimated by Odds ratio (ORs) with 95% confidence intervals (CIs). 19 studies (4239 cases and 5575 controls) were included for meta-analysis. A significant association was seen between individuals with MTHFR 677 CT [OR(95%)=1.47(1.32-1.63)] and TT [OR(95%)=1.69(1.49-1.91)] genotypes and ESCC risk (p<0.05). Low intake of folate had significantly higher risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.65(1.1-2.49)], while high intake of folate did not find significant high risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.64 (0.82-3.26)]. Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T.
Highlights
Esophageal cancer has been ranked as one of the most common malignancies worldwide.[1]Comparing with Comparing with esophageal adenocarcinoma which is one of the most prevalent cancer in Western Countries, and the major phenotype in Asian countries, especially in China, 1-4: Yang Shujuan, Wen YuanyuanZhang Jianxing, Chen Xin-yue, West China School of Public Heath, Sichuan University, Chengdu, China
We found individuals carrying CT+TT genotype and low intake of folate had an increased risk of ESCC risk when compared with CC genotype [OR(95CI%)=1.55(1.02-2.57)]
Our meta-analysis indicated Methylenetetrahydrofolate reductase (MTHFR) 677CT and/or TT genotypes are associated with the risk of ESCC, and folate could modify their association
Summary
Esophageal cancer has been ranked as one of the most common malignancies worldwide.[1]Comparing with Comparing with esophageal adenocarcinoma which is one of the most prevalent cancer in Western Countries, and the major phenotype in Asian countries, especially in China, 1-4: Yang Shujuan, Wen YuanyuanZhang Jianxing, Chen Xin-yue, West China School of Public Heath, Sichuan University, Chengdu, China. Esophageal cancer has been ranked as one of the most common malignancies worldwide.[1]. Comparing with Comparing with esophageal adenocarcinoma which is one of the most prevalent cancer in Western Countries, and the major phenotype in Asian countries, especially in China, 1-4: Yang Shujuan, Wen Yuanyuan. Received for Publication: Revision Received: Revision Accepted: January 3, 2013 is esophageal squamous cell carcinoma(ESCC). China, and it is estimated there are new diagnosed. Possible risk factors for ESCC include smoking and drinking habits, high intake of hot-temperature food, salted food and pickled vegetables, low intake of vegetable, chronic mucosal irritation.[2,3,4,5] It is reported that deficiency of nutrients, such as vitamins and microelements, is association with an enhanced risk for ESCC.[5]
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