Abstract
BackgroundA number of studies have explored the association between methyl enetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia (CIN). However, results remained controversial. To address this gap, we decided to conduct a meta-analysis of all available published studies.MethodsElectronic literature searches of the PubMed, EmBase and Medline databases were performed up to April 30, 2012. Fixed-effects or random-effects model was used to calculate the pooled ORs for different genetic models.ResultsA total of 12 case-control studies were ultimately identified. No statistical correlation was found between C677T variants and cervical cancer for the overall population. However, subgroup analyses on the White women pointed to a significant protective effect for individuals heterozygous or homozygous for the T-allele (for CT vs. CC: OR = 0.72, 95% CI 0.59–0.88; for TT vs. CC: OR = 0.69, 95% CI = 0.49–0.97; for CT+TT vs. CC: OR = 0.71, 95% CI 0.59–0.86). C677T variants were associated with neither combined nor stratified CIN among the overall population.ConclusionsThis meta-analysis suggests that White women with mutant C677T genotypes might have a lower risk of cervical cancer, yet lacking enough statistical robustness. Further investigations are needed to get more insight into the role of this polymorphism in cervical carcinogenesis.
Highlights
Cervical cancer is second only to breast cancer as the most common malignancies in both incidence and mortality among women worldwide, accounting for over 471,000 new cases and250,000 deaths globally each year [1,2]
Subgroup analyses on the White women pointed to a significant protective effect for individuals heterozygous or homozygous for the T-allele
C677T variants were associated with neither combined nor stratified cervical intraepithelial neoplasia (CIN) among the overall population. This meta-analysis suggests that White women with mutant C677T genotypes might have a lower risk of cervical cancer, yet lacking enough statistical robustness
Summary
Cervical cancer is second only to breast cancer as the most common malignancies in both incidence and mortality among women worldwide, accounting for over 471,000 new cases and250,000 deaths globally each year [1,2]. Cervical cancer is second only to breast cancer as the most common malignancies in both incidence and mortality among women worldwide, accounting for over 471,000 new cases and. Cervical intraepithelial neoplasia (CIN) is estimated to have at least 600,000 new cases per year [3], making (pre)neoplastic cervical disease a major public health threat and heavy burden to the society, especially in some high prevalent countries, such as India [4], Korea [5] and America [6]. Epidemiologic observations have implicated that infection with certain oncogenic types of human papillomavirus (HPV) is a major cause of cervical neoplasia [7]. To address this gap, we decided to conduct a meta-analysis of all available published studies
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