Abstract
Hyperhomocysteinemia is a well-established risk factor for cardiovascular disease and hypertension. This study aimed to assess the MTHFR gene polymorphisms (677C/T) as a potential genetic risk factor for hypertension and Myocardial Infarction (MI) in Egypt. Myocardial infarction and hypertensive diagnosed patients were divided into two groups; first comprised 50 patients aged 45 years and a third control group comprised 84. CT genotype was significantly higher in the first group (48.8%) versus control group (30%) and second group (29.4%) with (OR 2.35, 95% CI 1.3-4.2, p = 0.006). The percentage of TT genotype was 4.7, 11.8 and 15% in the three groups respectively. The percentage of MTHFR 677C→T polymorphism was significantly higher in patients with hypertension than normotensive. MTHFR 677C→T polymorphism in Egyptian MI and hypertensive patients has no direct role in developing such diseases but in combination with high levels of cholesterol, LDL-C and triglycerides might constitute a probable potentiating factor for MI and hypertension among Egyptian patients and could not be used as a predictor for early diagnosis without considering other factors.
Highlights
Myocardial Infarction (MI) and Hypertension are well-known prevalent disorders among Egyptians
MTHFR 677C→T polymorphism in Egyptian MI and hypertensive patients has no direct role in developing such diseases but in combination with high levels of cholesterol, LDL-C and triglycerides might constitute a probable potentiating factor for MI and hypertension among Egyptian patients and could not be used as a predictor for early diagnosis without considering other factors
Genotyping of patients two subgroups showed younger patients group was significantly different than older patients group for both CT and TT alleles
Summary
Myocardial Infarction (MI) and Hypertension are well-known prevalent disorders among Egyptians. Inadequate data were published concerning Coronary Artery Disease (CAD) susceptibility in Egyptian patients in terms of their genetic background. The aim of this work is to study the presence of MTHFR gene polymorphisms as a genetic risk factor for hypertension and MI among Egyptian patients. Morbidity and mortality due to Essential Hypertension (ET) and CAD are significant more frequent in developing countries with associated several risk factors such as advancing age, male gender, hyperlipidemia, diabetes and insulin resistance (Laraqui et al, 2007). Acute Myocardial Infarction (MI) among young adults is about 5 and 10% of all MIs (Choudhury and Marsh, 1999; Doughty et al, 2002). MI in young patients is resulted from multiple pathogenetic mechanisms; coronary spasm, coronary embolism and thrombus formation resulted from non-obstructive plaque rupture and endothelial layer erosion separately or in combination (Kardasz and Caterina, 2007; Verheugt et al, 1987; Romagnoli and Lanza, 2007)
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