Abstract
Following the reports of Sahlin,1 Eddy,2 Brooks,3 Geiger,4 Hanzlik,5 Hug,6 and Wendel,7 we investigated the comparative antidotal action of methylene blue and amyl nitrite in cyanide poisoning and found that methylene blue detoxified 2 M.L.D.'s and amyl nitrite by inhalation 4 M.L.D.'s of sodium cyanide.8 Amyl nitrite is thus twice as effective as methylene blue. To date we have studied other nitrites and sodium thiosulphate. The last compound has been shown to have an antagonistic action against cyanide by several investigators.9-13 The results summarized in Table I were all obtained in dogs. It should be noted that nitroglycerine is ineffective as an antidote; while sodium thiosulphate detoxifies 3 M.L.D.'s and sodium nitrite 4 M.L.D.'s of sodium cyanide. A more striking antidotal effect is exhibited when amyl or sodium nitrite is supplemented with sodium thiosulphate. The combination of the nitrite and thio-sulphate does not only show synergistic action but surpasses the sum of their individual values....
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