Abstract
Preservatives can be a frequent cause of allergic contact dermatitis (ACD). A quantitative risk assessment (QRA) method for identifying safe exposure levels has been suggested as a more effective tool for this purpose. This work assesses the validity of QRA by its retrospective application to the sensitizing preservative methyldibromoglutaronitrile (MDGN), which has recently been associated with unacceptable exposure levels in consumer products. Using a recently published QRA analysis of 4 preservatives in 5 consumer product types, the accuracy of the predictions for MDGN was assessed in light of what is known clinically about the nature and incidence of ACD to this material. Based on a local lymph node assay (LLNA) EC3 value (concentration of test chemical required to provoke a 3-fold increase in lymph node cell proliferation) of 0.9% in a weight-of-evidence approach to the identification of thresholds for the induction of skin sensitization, it can be determined that the acceptable levels of exposure to MDGN in a range of products range from as little as 25 ppm to in excess of 10,000 ppm. Thus, proactive use of QRA, used conservatively and in combination with expert judgment, would have limited the problem of ACD to this new preservative that is known to have caused problems on the consumer market.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.