Abstract
METHYLCELLULOSE (MC) is a long-chain polymer, a methyl ether of cellulose which forms a colloidal suspension. It is not absorbed from the alimentary tract. After intraperitoneal or intravascular injection of amounts comparable to those used in this study, the following changes are among those which have been observed: hypersplenism and hemolytic anemia<sup>1</sup>; a nephrotic-like syndrome due to renal damage induced by MC<sup>2</sup>; increase in circulating gamma globulin due to the appearance of a new gamma globulin fraction<sup>1</sup>; decrease in hemolysin formation<sup>1</sup>; and storage of large amounts of MC in endothelial cells of glomeruli and macrophages, especially in the spleen and liver. <h3>Materials and Methods</h3> Nonlittermate male Sprague-Dawley rats weighing from 300 to 360 gm were divided into groups which averaged 340- to 350-gm. All animals were on laboratory rat chow diet and water ad libitum throughout the studies. The subcutaneous transplantation of the lymphosarcoma and
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
