Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) robustly detects and distinguishes 11p15 abnormalities associated with overgrowth and growth retardation

R H Scott,N Rahman,L Baskcomb,T R Cole,J Douglas,D M Eastwood,J Bliek,K Tatton-Brown,P Lupunzina,E R Maher,S Garcia-Minaur,A O Nygren,V Cormier-Daire,J M Birch

doi:10.1136/jmg.2007.053207

Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) robustly detects and distinguishes 11p15 abnormalities associated with overgrowth and growth retardation

R H Scott, N Rahman + Show 12 more

https://doi.org/10.1136/jmg.2007.053207

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Journal: Journal of Medical Genetics	Publication Date: Oct 15, 2007
Citations: 101

Affiliation: Institute of Cancer Research, University College London, Great Ormond Street Hospital, Academic Medical Center, St George's Hospital, Autonomous University of Madrid, Hospital Universitario La Paz, Hôpital Necker-Enfants Malades

#Methylation-specific Multiplex Ligation-dependent Probe Amplification #Methylation-specific Multiplex Ligation-dependent Probe Amplification Assay + Show 8 more

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Background:A variety of abnormalities have been demonstrated at chromosome 11p15 in individuals with overgrowth and growth retardation. The identification of these abnormalities is clinically important but often technically difficult. Methylation-specific...

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