Abstract
Methylation pattern of tumor-suppressor gene promoters as putative noninvasive diagnostic markers for prostate cancer
Highlights
Prostate cancer (PCa) is one of the most abundant malignancies among men worldwide [1]
In our previous work we described the differential expression of those genes in PCa compared to the paired conventionally normal tissues (CNT), which pointed to their potential role in development of PCa, and, especially, in epithelial-mesenchymal transition [9]
NKX3.1 and KRT18 were highly methylated whereas the methylation of PTEN and CDH1 was low
Summary
Prostate cancer (PCa) is one of the most abundant malignancies among men worldwide [1]. In Ukraine, the number of PCa new cases in 2018 was estimated as 7 936 (Cancer today https://gco.iarc.fr/). It is important to seek additional PCa diagnostic markers of high sensitivity and specificity as well as the markers for estimation of disease severity and prediction of its progression. Many various cell populations with different methylome can be found in PCa lesions. Due to this fact, the quantitative analysis of gene methylation patterns and comparison with clinical tumor characteristics are needed to shed the light on a role of methylation events in PCa development [5, 6]
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