Abstract
IntroductionPattern recognition receptors, such as toll-like receptor 2 (TLR-2) and TLR-4, participate in the activation of immune cells by microorganisms in dental pulp. However, the expression levels of pattern recognition receptors can be modulated by epigenetic factors, especially DNA methylation. In this study, the methylation status of the TLR-2 and CD14 (TLR4 co-receptor) genes in healthy and inflamed human dental pulp was examined. MethodsThe Methyl-Profiler DNA Methylation qPCR Assay was used to verify the DNA methylation patterns. ResultsNo differences in the methylation patterns were observed between the 2 groups. Most DNA was unmethylated in both groups. ConclusionsThe hypomethylation of TLR2 and CD14 genes is a usual feature in human dental pulp.
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