Abstract
THE need for a compound which stimulates general tissue growth has led to examination of a number of agents by several methods of assay. The final test of clinical usefulness of such a compound is its ability to produce an increment of tissue in man as measured by weight, height, and metabolic balance studies. The hormones found to be potent in this respect are also strongly androgenic, a quality which limits their clinical application. Although the growth hormone of the anterior pituitary gland fulfills the criteria of tissue growth in animal experimentation and is devoid of androgenic activity, existing preparations of this hormone have been disappointing in man (1, 2). Previous experiments have suggested that the androgenic potency of the steroids does not necessarily parallel their anabolic activity (3). These studies have also indicated that the weight of the levator ani muscle of the castrate male rat reflects the anabolic efficacy of administered steroids. This muscle is restored to normal, or even...
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
