α-Methylacyl Coenzyme A Racemase, Ki-67, and Topoisomerase IIα in Cystoprostatectomies With Incidental Prostate Cancer

Abstract

alpha-Methylacyl coenzyme A racemase (AMACR), Ki-67, and topoisomerase IIalpha were immunohisto-chemically evaluated in prostate carcinoma (PCa), high-grade prostatic intraepithelial neoplasia (HPIN), normal-looking epithelium (NEp), and atrophy in 20 cystoprostatectomy (CyP) and 20 radical prostatectomy (RP) specimens with pT2a Gleason score 6 PCa. The aim was to see whether there were differences in marker expression between CyP and RP specimens. The results showed that the proportions of AMACR-, Ki-67-, and topoisomerase IIalpha-positive cells in the CyP and RP specimens increased from NEp and atrophy through HPIN, away from and adjacent to PCa, to PCa. AMACR expression in PCa in CyP specimens was slightly lower than in RP specimens, but the differences were not significant; there were significant differences in Ki-67 and topoisomerase IIalpha indices. Our findings in marker expression in NEp, atrophy, and HPIN suggest that there are some differences in the field effects in terms of prostatic carcinogenesis between CyP and RP specimens.