Abstract
Free Fatty acid is an end-product of hepatic metabolism of fructose. Most of past studies have demonstrated significant relationship between gestational high fat diet and metabolic and physiology outcomes in offspring. However, there is a scarce of data extended to the effects of high fructose diet-fed dams on juveniles’ progeny. Therefore, the present experiment was designed to examine the later effects of maternal high fructose diet intake during pregnancy and lactation on juvenile offspring rats emotional behaviors and memory abilities. We tested whether methyl donors supplemented to that high fructose diet could reverse the adverse effects. We found at two months of age, anxiety-like behavior and depression-like behavior were elevated in off springs of mother fed to high fructose diet and a sex difference effect with males were more affected than females. In addition, behavioral outcomes indicated that the high fructose diet also impaired spatial working and recognition memories in the Y-maze and object recognition test respectively. Blood glucose intolerance increased significantly in juvenile males rats of dams fed with high fructose diet when compared to females. However, a supplementation of the maternal diet with methyl donors attenuated all these changes. Our study suggested a controlled fructose diet supplemented to methyl donors during critical period of brain developing (in utero and pre-weaning stage), otherwise that could induced irreversible detrimental effects on offspring behavior and cognitive health.
Highlights
Fructose is a monosaccharide compound present in significant quantities in fruit, soft drink and others sweetened beverages, and commonly found in western countries people diets
We found at two months of age, anxiety-like behavior and depression-like behavior were elevated in off springs of mother fed to high fructose diet and a sex difference effect with males were more affected than females
Current study examines for first time the risk of maternal nutritionnal programming with high fructose-diet (HFD) during pregnancy and lactation on emotional and cognitive behaviors of the offspring, and whether methyl donors supplementation diet may reverse to that
Summary
Fructose is a monosaccharide compound present in significant quantities in fruit, soft drink and others sweetened beverages, and commonly found in western countries people diets. A past study had investigated the relation to dams fed with specific diet (high fat deprived of methyl donors) during pregnancy and lactation, and offspring physiology effects such as a global decrease of DNA methylation (essential factor in gene expression control) within the brains of males offspring [6]. Taken together, these are risk factors for neuroinflammatory diseases such asdiabetes, cardiovascular diseases, hypertension and brain diseases [7] [8] [9] [10]
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