Abstract
4-Methoxyphenylethylamine was found to be a specific substrate for type B monoamine oxidase (MAO) in rat brain mitochondria, whereas 3,4-dimethoxyphenylethylamine was common for both types of MAO. These results suggest that O-methylation in the para-position increases the preference of the substrate for type B MAO, while a methoxy-group in the meta-position contributes to the substance being a type A substrate.
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