Abstract
The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration, Poly Vinyl Alcohol (PVA) concentration in the external phase and drug concentration on the particle size was evaluated.
Highlights
Glioblastoma Multiforme (GBM) is considered as the most common and lethal primary brain tumor as well as the most malignant neoplasm of the astrocytic regions, accounting for 15% of all primary brain tumors, about 5060% of all astrocytomas and 60 to 70% of malignant gliomas [1,2,3]
Numerous challenges and obstacles exist for the treatment of these tumors including: First; challenges related to the specific characteristics of GBM tumors such as uncontrolled cell growth, high aggressive power, tendency to recurrent micro-vascular growth, resistance to apoptosis and genetic instability [6] and second; challenges related to Blood-Brain Barrier (BBB), Blood-Cerebrospinal Fluid Barrier (BCB) and Blood-Tumor Barrier (BTB) [7,8] as well as third; challenges related to chemotherapeutic agents and the drug delivery to glioblastoma tumors such as insufficient permeability of physiological barriers, general toxicity and drug resistance [9]
Various parameters can affect the physicochemical properties of NPs including polymer concentration, Polyvinyl Alcohol (PVA) concentration in the external phase and drug concentration which play an effective role on the particle size
Summary
Glioblastoma Multiforme (GBM) is considered as the most common and lethal primary brain tumor as well as the most malignant neoplasm of the astrocytic regions, accounting for 15% of all primary brain tumors, about 5060% of all astrocytomas and 60 to 70% of malignant gliomas [1,2,3]. Numerous challenges and obstacles exist for the treatment of these tumors including: First; challenges related to the specific characteristics of GBM tumors such as uncontrolled cell growth, high aggressive power, tendency to recurrent micro-vascular growth, resistance to apoptosis and genetic instability [6] and second; challenges related to Blood-Brain Barrier (BBB), Blood-Cerebrospinal Fluid Barrier (BCB) and Blood-Tumor Barrier (BTB) [7,8] as well as third; challenges related to chemotherapeutic agents and the drug delivery to glioblastoma tumors such as insufficient permeability of physiological barriers, general toxicity and drug resistance [9].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
