Abstract
Therapeutic peptides have high selectivity, efficacy, and low toxicity. These characteristics, combined with advances in solid-phase peptide synthesis and purification methods, have led to the widespread use of peptide-based drugs. Limitations in the research and development of peptide drugs are related to their short plasma half-life, rapid metabolism, proteolytic degradation and poor penetration through biological membranes. This mini-review examines the advantages of peptide drugs over small molecule drugs and biotechnological proteins, as well as various chemical methods for peptide modifications to increase the metabolic stability, bioavailability and pharmacokinetic properties of peptides.
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