Abstract
As an essential life-saving intervention, mechanical ventilation is also associated with 16 complications which result to higher medical costs and mortality (1,2). Therefore, it was essential to 17 liberate patients from mechanical ventilation efficacy and safety for the shortest possible duration. 18Despite many studies comparing the safety and effectiveness of different methods for weaning have 19 been published, many controversial questions remain concerning the best method for this process. 20Given that research to date have not investigated the comparative of all available modes of weaning 21 simultaneously, network meta-analysis may help evaluate relative effectiveness between all modes 22 from both direct and mixed-treatment comparisons (3). 23 Although, it is still controversial about the best method of liberation from mechanical 62 ventilation, new mode in line with respiratory physiology might be a light at the end of the tunnel. 63
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