Abstract
Ia antigens were shown to be present in the cell almost exclusively as mature αβ dimers which split into separate α and β chains after boiling in SDS. In contrast metabolically labelling the cells with [ 35S]methionine resulted in only free α and β chains being labelled. It is concluded that this widely used type of labelling, although useful for studying intermediate synthesis, should not be used for labelling mature cell surface molecules.
Published Version
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