Abstract
The relative biological effectiveness (RBE) of fast neutrons is an important factor influencing the quality of neutron therapy therefore, the assessment of RBE is of great importance. Experimental and clinical studies as well as different mathematical and radiobiological models are used for assessing RBE. Research is conducted for neutron sources differing in the method of producing particles, energy and energy spectrum. Purpose: to find and analyze the dose-dependence of fast neutron RBE in neutron therapy using the U-120 cyclotron and NG-12I generator. Material and methods: The optimal method for assessing the relative biological effectiveness of neutrons for neutron therapy was described. To analyze the dependence of the RBE on neutron dose, the multi-target model of cell survival was applied. Results: The dependence of the RBE of neutrons produced from the U-120 cyclotron and NG-120 generator on the dose level was found for a single irradiation of biological objects. It was shown that the function of neutron dose was consistent with similar dependencies found by other authors in the experimental and clinical studies.
Highlights
Важным фактором, влияющим на качество нейтронной терапии, является относительная биологическая эффективность (ОБЭ) нейтронов, поэтому количественной оценке этой величины уделяют значительное внимание
The relative biological effectiveness (RBE) of fast neutrons is an important factor influencing the quality of neutron therapy the assessment of RBE is of great importance
Experimental and clinical studies as well as different mathematical and radiobiological models are used for assessing RBE
Summary
Влияющим на качество нейтронной терапии, является относительная биологическая эффективность (ОБЭ) нейтронов, поэтому количественной оценке этой величины уделяют значительное внимание. Цель исследования – проанализировать зависимости ОБЭ нейтронов от дозы в дистанционной нейтронной терапии на циклотроне У-120 и генераторе НГ-12И. Для получения зависимости ОБЭ нейтронов от дозы применена многомишенная модель клеточной выживаемости.
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