Methods for Making a Nanosuspension of Poorly Soluble Medications

Abstract

Class II prescriptions are known to dissolve ineffectively in both natural and fluid solvents, making them a significantly more challenging challenge. When it comes to these kinds of high log P synthetic compounds that are insoluble in water, the nanosuspension structure is desired. The overall bioavailability of nanosuspensions is influenced by an increase in surface area and a decrease in molecule size. Sometimes the oral dosage forms of water-soluble drugs that are slowly absorbed and inefficient show insufficient bioavailability. A drug's permeability and solubility have a significant impact on how bioavailable it is. To create sub-micron-sized particles, a suitable emulsifier and a pharmaceutical mixture are fed through a high-pressure homogenization or milling procedure. Both classic milling and precipitation processes are commonly used to create particles larger than one millimetre. In this investigation, the techniques was used to prepare the nanosuspension for improving the solubility of poorly soluble drugs.