Abstract
To assess the influence of fibrinogen degradation products (FDP) on fibrinogen determinations, Clauss and Ratnoff-Menzie assays were performed with different concentrations of human plasma and FDP. When varied concentrations of plasma were mixed with an equal volume of FDP at a final titer of 1:512 (tanned red cell assay), fibrinogen levels were decreased by approximately 30% in the Ratnoff assay. Inhibition was overcome by clotting the fibrinogen in a smaller volume of saline. Inhibition was also corrected by clotting more concentrated mixtures of plasma and FDP with thrombin. The influence of FDP in fibrinogen assays is significant when low levels of fibrinogen are measured.
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