Abstract
Roche's AVENIO ctDNA analysis kits and bioinformatics analysis (the AVENIO system) areaccessible to all NGS laboratories. We have developed an approach, namelythe Sec-Seq system, andcompared the accuracy, sensitivity, repeatability and economic cost between the AVENIO system and the Sec-Seq system. Both methods share the comparable accuracy and sensitivity in detecting the variant allele frequency of 0.0005, while the Sec-Seq system shows better accuracy in detecting the variant allele frequency of 0.001. Furthermore, the Sec-Seq system displaysa much better detection sensitivity than the AVENIO system. The Sec-Seq system has satisfactory performance in detecting the rare genetic variants in ctDNA with lower economic cost compared with the AVENIO system.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have