METHODOLOGICAL ASPECTS OF INTERSPECIES EXTRAPOLATION OF EXPERIMENTAL DATA UNDER PULSED ACOUSTIC INFLUENCE ON BIOOBJECTS (REVIEW)

Abstract

Background. Despite a significant number of theoretical and experimental studies, the issue of determining the threshold levels of pulsed acoustic exposure, when exceeded, their negative effect on the morphofunctional state of a biological object begins to appear. Traditionally, in laboratory conditions, such estimates are obtained in experiments on animals, varying the parameters of exposure, followed by extrapolation of the results obtained to humans. However, the pathophysiological mechanisms of disturbances that develop in experimental animals as a result of impulse acoustic impacts have not been sufficiently studied in this context, and indicators of the state of the physiological systems of a biological object that are sensitive to acoustic impulses are not currently taken into account when determining their safe levels.
 Purpose. The purpose of the work was to analyze the pathophysiological mechanisms of the development of biological effects of pulsed low-intensity acoustic exposure at different levels of the organization of a living system and to develop a methodological approach to obtaining a quantitative assessment and extrapolation of data on such exposure from animals to humans, taking into account the physical parameters of the acoustic factor and characteristics of the state of the experimental biological object.
 Materials and methods. The selection and systematic review of the scientific literature on the topic of research by keywords in specialized bibliographic databases was carried out.
 Results. The analysis and generalization of the existing theories about the pathophysiological mechanisms of the biological action of acoustic impulses at different levels of the organization of a living system have been carried out. An original hypothetical scheme for interpreting the effects of acoustic exposure in animals is proposed, which is suitable for obtaining threshold estimates of the levels of the adverse effect of the factor on clinical parameters in experimental animals, and vulnerable critical links in the regulation of external respiration in mammals that cause the damaging effect of acoustic vibrations are identified. A scientific and methodological approach to interspecies extrapolation of medical and biological effects of exposure to low-amplitude air pressure waves from animals to humans has been developed, taking into account the anatomical and physiological parameters of the respiratory system of experimental animals, as well as the informative characteristics of the acoustic pulse. An empirical model is proposed that makes it possible to predict the threshold levels of the conditional power of adverse acoustic effects in humans using data on the development of lung damage in experimental animals of various biological species, and the features of setting up such a model are formulated.
 Conclusion. It has been substantiated that it is relevant to refine the proposed empirical model and develop a theoretical model for extrapolation of the initial experimental data on the threshold of safe acoustic exposure from animals to humans, taking into account the interspecific patterns of functioning of physiological systems of the body that are critical to the impact.