Methodological Approaches to Development of Cell-based Medicinal Product for Treatment of Patients with Cold Injury in the Arctic

Abstract

Frostbite is the most common type of traumatic injuries in the cold climate of the Arctic. Post-traumatic recovery of the patients takes a long time and often leads to the loss of the damaged limb. A promising approach for frostbite therapy could be treatment with mesenchymal stem/stromal cells (MSCs), which are widely used in regenerative medicine for different applications. Here, we aimed to discuss the possibility of frostbite treatment with MSCs. The success of MSC use for therapy of different injures depends on multiple factors including the source and functional state of MSCs. These aspects along with strategies for improvement of therapeutic effect of MSC treatment are also discussed in detail.