Abstract
Determination of in-vivo tissue optical properties for anal photodynamic therapy (PDT) is challenging due to the light integrating-sphere effect in an enclosed cylindrical cavity. We developed a model for optical properties determination for anal PDT from measurements of light fluence rate inside a cylindrical cavity submerged in tissue-mimicking liquid phantoms. Measurements are performed in a set of phantoms with known optical properties (μa = 0.1-0.9 cm-1) and (μs’ = 6.65-19.95 cm-1) and the primary and scatter light fluence rates are determined. We developed an analytical expression to relate scatter light fluence rate measured in an enclosed cylindrical geometry to the surrounding tissue optical properties in tissue-simulating liquid phantoms. In addition, the accuracy of determining tissue optical properties using the model was evaluated by comparing the recovered optical properties to the known optical properties of a series of independent test phantoms.
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