Method optimization for obtaining of “Hawthorn fruit tincture”

Abstract

The fruits of various species of the genus Crataegus L. contain flavonoids and are widely used in domestic and foreign medicine for the production of cardiotonic drugs. Crataegus submollis Sarg. is grown in our country as the edible and ornamental plant, but it is not currently used in medicine. Fruit juice of Crataegus submollis Sarg. exerts diuretic effect and an antidepressant activity. Dried fruit pulp can be used to produce extraction preparations. The aim of the work is to compare and analyze the samples of tinctures obtained from the fruits of the Crataegus submollis Sarg. and the pulp of its fruits. Tinctures based on 70% ethyl alcohol were obtained on the basis of dried fruits of Crataegus submollis Sarg. and the pulp of its fruits. The quality of the obtained tinctures was studied by determining of the total amount of flavonoids. Tinctures made of dried pulp of Crataegus submollis Sarg. fruits are as good as industrial samples of preparations in terms of flavonoid content. The fruits of the Crataegus submollis Sarg. and the pulp of its fruits can serve as medicinal plant raw materials for obtaining tinctures.