METHOD OF RECONSTRUCTION OF POLYCRYSTALLINE STRUCTURE OF HISTOLOGICAL CUTS IN DETERMINATION OF THE STATURE OF FORMATION OF DAMAGES OF INTERNAL BODIES

Abstract

The article presents the results of algorithmic testing of methods of digital histologicalstudy of the age of damage to brain, liver and kidney tissues based on polarization reconstruction of maps of linear birefringence of protein fi brillar networks; determining the relationships between the temporal change in the magnitude of statistical moments of the 1st – 4th orders, which characterize the distributions of the magnitude of the degree of crystallization of histological sections of the brain, liver and kidney and the duration of damage; establishment of time intervals and accuracy of determining the age of damage to human internal organs by digital histological methods of polarization reconstruction (tomography) of the degree of crystallization.Aim of the work. Development of algorithmic methods of digital histological study of the duration of damage to brain, liver and kidney tissues based on polarization reconstruction of linear birefringence maps of protein fi brillar networks.Materials and methods. The object of the study was the histology of samples of human internal organs (myocardium, lung tissue) with diff erent duration of damage (from 1 to 120 hours). For control, we used BT samples from those who died from coronary artery disease with diff erent duration of damage (from 1 to 120 hours).Results. For the fi rst time, the main relationships between temporal changes in the statistical structure of topographic maps of the degree of crystallization of histological sections of human internal organs and variations in the magnitude of statistical moments of the 1-4th orders that characterize them.Conclusions. The time ranges of linear change of variations in the value of statistical indicators of tomographic methods of digital histology and the accuracy of determining the duration of damage.