Method of Prediction the Development of Arterial Hypertension in Type 1 and 2 Diabetes

Abstract

The objective: to create a mathematical model of prediction the development arterial hypertension in type 1 and type 2 diabetes based on traditional risk factors for cardiovascular diseases and the serum level of vascular endothelial factors.Materials and methods. The study was attended by 97 people. We examined 33 type 1 diabetes patients: 23 hypertensive and 10 nonhypertensive. Also 64 type 2 diabetes patients: 41 hypertensive and 23 non-hypertensive. Were studied BMI, blood glucose, HbA1c, total cholesterol, HDL, LDL, triglycerides, insulin, HOMA, Caro, serum level of EMAP-II, fibronectin, VEGF, ICAM-1, VCAM-1, E-selectin by immunoenzyme assay in all patients. Endothelial-dependent dilatation was investigated by Celermajer metod. Static analysis was performed by metod of logistic regression.Results. In type 1 diabetes patient, among 15 factors, 3 were selected that had a provocative effect on the development of arterial hypertension: blood glucose, EMAP-II, fibronectin. In type 2 diabetes patients, among 18 factors, 5 were identified, the combination of which had a provocative effect on the development of arterial hypertension: BMI, HbA1c, triglycerides, ICAM-1, endothelial-dependent dilatation. A computer program «Estimation of prediction the development arterial hypertension in diabetes mellitus» has been launched based on the obtained mathematical formulas.Conclusion. A computer program «Estimation of prediction the development arterial hypertension in diabetes mellitus» and mathematical models, which formed the basis for it, allow identifying risk factors for arterial hypertension in type 1 and type 2 diabetes patients. Early started preventive work, continuous monitoring of risk factors helps prevent the development of arterial hypertension in these patients.