Abstract
Seven phenothiazine derivatives (PHE) group were studied using non-aqueous capillary electrophoresis (NACE). The screening and quantification method for these drugs in blood was presented. Then the optimal medium for dissolution of the examined blood extracts was tested for. The precision of identification and quantification parameters comprised the ranges from 0.29 to 1.38 and from 1.21 to 9.15 % RSD, correspondingly. The detection limits were 0.08 for promazine and 0.15 μg mL−1 for the rest of drugs tested. The correlation coefficient of the method linearity was studied over the concentration range of 0.25–4.00 μg mL−1 and was higher than 0.996. Finally the proposed method was applied to two forensic blood samples and concentrations of the examined phenothiazines determined by HPLC and NACE methods were found to be comparable.
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