Abstract
To relate structural (anatomical) and functional (behavioral) measures of glaucomatous damage, a method is described for comparing visual field defects to local retinal ganglion cell (RGC) and retinal nerve fiber layer (RNFL) thicknesses. Thickness maps of the RNFL and the RGC + inner plexiform layer, obtained with frequency domain optical coherence tomography (fdOCT), were transformed into probability maps by comparing them to a normative group. As demonstrated in patients with glaucomatous damage to the macula, the probability map associated with the patient’s visual field can be directly compared to the fdOCT probability maps by taking into consideration the displacement of the RGCs.
Highlights
Glaucoma is a progressive optic neuropathy that damages the retinal ganglion cells (RGC) and their axons
To relate structural and functional measures of glaucomatous damage, a method is described for comparing visual field defects to local retinal ganglion cell (RGC) and retinal nerve fiber layer (RNFL) thicknesses
As the variance in OCT and visual fields measures should be independent, the visual field and OCT probabilities can be mathematically combined to improve the sensitivity/specificity of these tests
Summary
Glaucoma is a progressive optic neuropathy that damages the retinal ganglion cells (RGC) and their axons. With the newer frequency domain (fd) OCT, it is possible to measure the thickness of the two layers damaged by glaucoma, the retinal nerve fiber layer (RNFL), which contains the axons of the RGCs, and the RGC plus the inner plexiform layer (IPL), which contains the RGC bodies as well as the connections of the cells of the inner nuclear layer to these RGCs (e.g., [3,4,5,6,7]). Our purpose here is to describe a method for comparing spatially local visual field defects to local RGC + IPL and RNFL thicknesses. We illustrate this method by applying it to patients with glaucomatous damage to the macula
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