Abstract
A simple, highly sensitive, isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed for the determination of nevirapine in the bulk drug and tablet dosage forms and it was applied for the in vitro drug dissolution studies. Elution medium consisting of a mixture of methanol and water in the ratio of (89:11, v/v) at flow rate 1ml/min was employed in this study. The retention time of nevirapine was found 3.14 min. The calibration curves were linear with regression coefficient (r2) of 0.9999. The proposed method was extensively validated for linearity, range, accuracy, precision and specificity. The proposed method is sensitive, specific and was successfully applied for the estimation of nevirapine in pharmaceutical formulations (bulk drug and tablet) and in vitro dissolution studies.
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