Abstract
Because of their capacity to permeate across the stratum corneum’s barriers to penetration, transferosomes are one of the vesicular transporters that have recently attracted a lot of research and attention. The current study aimed to analyze and improve methocarbamol transferosomal transdermal gels. Reverse phase evaporation was used to create thirteen different formulations of methocarbamol-loaded transfersomes. Using face-centered central composite designs, the influence of independent process variables, like soy lecithin content and surfactant concentration, on dependent variables, such as entrapment effectiveness and the vesicle size of methocarbamol transfersomes, was assessed. The ex-vivo permeation flux of methocarbamol and the lipid to surfactant ratio/skin absorption efficiency of the drug and transferosomal gels were optimized. The optimized formulation showed an entrapment efficiency of 95%, a vesicle diameter of 428 nm, a drug content of 96.6% and a zeta potential of −28.9 mV. In-vitro and ex-vivo drug release rate in optimised gels was found to be 86.43 and 84.12% for 24 hours, respectively. This tranferosomal delivery method for transdermal methocarbamol may be preferable to the standard of care.
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