Year-end Sale % OFF 
Abstract
BackgroundSkin and soft tissue infections (SSTIs) due to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) can lead to a number of significant known medical outcomes including hospitalization, surgical procedures such as incision and drainage (I&D), and the need for decolonization procedures to remove the bacteria from the skin and nose and prevent recurrent infection. Little research has been done to understand patient and caregiver-centered outcomes associated with the successful treatment of MRSA infection.ObjectiveThis study aimed to uncover MRSA decolonization outcomes that are important to patients and their parents in order to create a set of prototype measures for use in the MRSA Eradication and Decolonization in Children (MEDiC) study.MethodsA 4-hour, human-centered design (HCD) workshop was held with 5 adolescents (aged 10-18 years) who had experienced an I&D procedure and 11 parents of children who had experienced an I&D procedure. The workshop explored the patient and family experience with skin infection to uncover patient-centered outcomes of MRSA treatment. The research team analyzed the audio and artifacts created during the workshop and coded for thematic similarity. The final themes represent patient-centered outcome domains to be measured in the MEDiC comparative effectiveness trial.ResultsThe workshop identified 9 outcomes of importance to patients and their parents: fewer MRSA outbreaks, improved emotional health, improved self-perception, decreased social stigma, increased amount of free time, increased control over free time, fewer days of school or work missed, decreased physical pain and discomfort, and decreased financial burden.ConclusionsThis study represents an innovative HCD approach to engaging patients and families with lived experience with MRSA SSTIs in the study design and trial development to determine meaningful patient-centered outcomes. We were able to identify 9 major recurrent themes. These themes were used to develop the primary and secondary outcome measures for MEDiC, a prospectively enrolling comparative effectiveness trial.Trial RegistrationClinicalTrials.gov NCT02127658; https://clinicaltrials.gov/ct2/show/NCT02127658
Highlights
Community-acquired skin and soft tissue infections (SSTIs) such as cellulitis, boils, myositis, and abscesses caused by antibiotic-resistant bacteria known as methicillin-resistant Staphylococcus aureus (MRSA) have risen dramatically over the past 20 years, and a significant proportion of these affect otherwise healthy children [1,2,3,4,5,6,7,8]
The estimated incidence of hospitalizations due to MRSA SSTIs is more than 45 per 100,000 children, with many children requiring surgical procedures such as incision and drainage (I&D), to drain pus caused by the infection [6,9,10]
The MRSA Eradication and Decolonization in Children (MEDiC) comparative effectiveness trial [20] aimed to assess the effectiveness of 2 interventions: (1) abscess surgery and hygiene education compared with (2) abscess surgery and hygiene education followed by decolonization
Summary
Community-acquired skin and soft tissue infections (SSTIs) such as cellulitis, boils, myositis, and abscesses caused by antibiotic-resistant bacteria known as methicillin-resistant Staphylococcus aureus (MRSA) have risen dramatically over the past 20 years, and a significant proportion of these affect otherwise healthy children [1,2,3,4,5,6,7,8]. One strategy, called decolonization, focuses on eradicating the presence of bacteria on the skin and in the nose of people at risk of infection. Skin and soft tissue infections (SSTIs) due to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) can lead to a number of significant known medical outcomes including hospitalization, surgical procedures such as incision and drainage (I&D), and the need for decolonization procedures to remove the bacteria from the skin and nose and prevent recurrent infection. Little research has been done to understand patient and caregiver-centered outcomes associated with the successful treatment of MRSA infection
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
