Abstract
We performed a longitudinal analysis of 661 methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from patients in a long-term care facility. USA300 clone increased from 11.3% of all MRSA isolates in 2002 to 64.0% in 2006 (p<0.0001) and was mostly recovered from skin or skin structures (64.3% vs. 27.0% for non-USA300 MRSA; p<0.0001).
Highlights
Since 2001, a dramatic increase in methicillin-resistant Staphylococcus aureus (MRSA) infections has been observed in the United States, mostly related to emergence of the USA300 clone in the community [1] and subsequently in hospitals [2,3]
Nonduplicated MRSA isolates were genotyped by pulsed-field gel electrophoresis (PFGE) after digestion of chromosomal DNA with SmaI [6], spa typing [7], and multilocus sequence typing (MLST) [8]
This decrease was not observed in this long-term care facilities (LTCFs), where the incidence of the previously predominant clone USA100 remained unabated
Summary
Since 2001, a dramatic increase in methicillin-resistant Staphylococcus aureus (MRSA) infections has been observed in the United States, mostly related to emergence of the USA300 clone in the community [1] and subsequently in hospitals [2,3]. For MRSA specimen sources, we observed a decrease in the proportion of urinary or respiratory specimens from 69.7% (131/188) during 1997–2000 to 49.5% (236/477) during 2001–2006, and a concomitant increase in the proportion of skin or skin structure specimens from 22.3% (42/188) to 42.8% (204/477) (p
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