Abstract
Methicillin-resistant Staphylococcus aureus of clonal lineage ST398 that exhibits related spa types and contains SCCmec elements of types IVa or V has been isolated from colonized and infected humans and companion animals (e.g., dog, pig, horse) in Germany and Austria. Of particular concern is the association of these cases with cases of nosocomial ventilator-associated pneumonia.
Highlights
Methicillin-resistant Staphylococcus aureus of clonal lineage ST398 that exhibits related spa types and contains staphylococcal cassette chromosome mec (SCCmec) elements of types IVa or V has been isolated from colonized and infected humans and companion animals in Germany and Austria
We report on molecular characterization of Methicillin-resistant Staphylococcus aureus (MRSA), from sporadic infections in humans and in various animal species, that belong to clonal lineage ST398 according to multilocus sequence typing (MLST)
A peculiarity of S. aureus of clonal lineage ST398 is the indigestibility of whole cellular DNA by restriction enzyme SmaI
Summary
Methicillin-resistant Staphylococcus aureus of clonal lineage ST398 that exhibits related spa types and contains SCCmec elements of types IVa or V has been isolated from colonized and infected humans and companion animals (e.g., dog, pig, horse) in Germany and Austria. The emergence and spread of MRSA in the community during the past 5 years, independent of the healthcare setting and in the absence of typical risk factors for nosocomial MRSA infections, are matters of further concern. We report on molecular characterization of MRSA, from sporadic infections in humans and in various animal species, that belong to clonal lineage ST398 according to multilocus sequence typing (MLST) These isolates were further characterized by spa-sequence typing (repeat polymorphism of the X-region of the spa gene) and by PCR for grouping of staphylococcal cassette chromosome mec (SCCmec) elements, which contain the mecA gene and of which at least 5 basic types have been described
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