Abstract
Two independent surveys of the frequency of methicillin resistance in Staphylococcus aureus indicate that there was a moderate increase between 1960 and 1963, followed by a stationary period. A second increase began in 1968 and is continuing. Resistant strains have been present in many hospitals for some years, and the more recent increase in frequency seems to be due to their wider dissemination among the patients. The spread of methicillin-resistant staphylococci is probably encouraged by the use of all penicillins and related antibiotics.
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