Abstract
The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats' liver. Thiol groups' oxidation, amyloid cross-β, and protein fragmentation (P < 0.001) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (P < 0.05). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.
Highlights
Free radicals are involved in many chronic and acute disorders such as diabetes, cancer, cardiovascular disease, immunosuppression, and neurological problems [1]
The previous reports have not investigated all of the antioxidant indices of Anethum graveolens, neither its antiglycation effects
Total flavonols content of dill was determined by adding of 1 mg/mL dill extract to the reaction solution (200 μL of 20 mg/mL AlCl3) + 6 mL sodium acetate solution (50 mg/mL)
Summary
Free radicals are involved in many chronic and acute disorders such as diabetes, cancer, cardiovascular disease, immunosuppression, and neurological problems [1]. The detrimental effects of the free radicals can be blocked by natural antioxidants [2]. Dill is used for various purposes in many countries and traditionally used for medicinal purpose such as digestive disorders, reduction of the bad breath, and stimulation of lactation and known as a lipid lowering, anticancer, antimicrobial, antidiabetic, antigastric irritation, anti-inflammatory, and antioxidant agent [4, 5]. Dill showed potential antidiabetic activity [10]. The previous reports have not investigated all of the antioxidant indices of Anethum graveolens, neither its antiglycation effects. This study was planned to assess the antiglycation and oxidant scavenging as well as hepatoprotective effects of dill cultivated in Hamadan (west of Iran)
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