Abstract
Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains.
Highlights
There is a high societal demand for – and scientific interest in – more environmental-friendly and sustainable production processes for large quantity bulk products
Cadaverine secretion has been a target for optimization of production (Kind et al, 2011; Li et al, 2014). These production processes rely on E. coli and Corynebacterium glutamicum as microbial hosts using sugars from molasses or from starch hydrolysis as carbon and energy substrates leading to an unwanted competition with human food supply, and nutrition prices are rising worldwide (Schrader et al, 2009)
We have investigated the potential of methanol-based biotechnological production of cadaverine at elevated temperature using wild-type and mutant B. methanolicus strains as hosts
Summary
There is a high societal demand for – and scientific interest in – more environmental-friendly and sustainable production processes for large quantity bulk products. Applying bacteria as microbial production hosts, certain polyamines can be obtained from amino acids including L-lysine, L-arginine and L-ornithine by thermodynamically favourable decarboxylation reactions (Schneider and Wendisch, 2011). Cadaverine secretion has been a target for optimization of production (Kind et al, 2011; Li et al, 2014) These production processes rely on E. coli and Corynebacterium glutamicum as microbial hosts using sugars from molasses or from starch hydrolysis as carbon and energy substrates leading to an unwanted competition with human food supply, and nutrition prices are rising worldwide (Schrader et al, 2009). E.g. recombinant C. glutamicum strains have been developed to accept alternative carbon sources such as glycerol from the biodiesel process (Meiswinkel et al, 2013a), amino
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